Dynein light intermediate chain binding

Author: gsmk

August undefined, 2024

WebAug 30, 2024 · Further, we noticed that the N-terminus of kazrin C shares homology with dynein/dynactin adaptors and that it directly interacts with the dynactin complex and the dynein Light Intermediate Chain 1 (LIC1). Altogether, the data indicate that one of the primary kazrin functions is to facilitate endocytic recycling via the perinuclear endocytic ... WebShop Target Dulles Store for furniture, electronics, clothing, groceries, home goods and more at prices you will love.

UniProt

WebMar 4, 2024 · The cytoplasmic dynein light intermediate chains (LICs) 1 and 2 are cargo-binding subunits, though their relative roles are not well understood. Here, we used in utero electroporation of shRNAs or LIC functional domains to determine the relative contributions of the two LICs in the developing rat brain. WebMar 30, 2024 · The light-intermediate chain has a Ras-like fold and appears to bind to nucleotides (Schroeder et al., 2014; Toropova et al., 2024). Although nucleotide-binding by the light-intermediate chain does not seem essential for dynein-2 function (Hou et al., 2004), whether it serves a structural role or has a minor regulatory function remains unclear. small businesses near me clothing

Multivalency, autoinhibition, and protein disorder in the ... - Sciety

WebThe dynein light intermediate chain . 2. The dynein accessory proteins Lis1, Nde and Ndel-1 . This will be achieved by studying and manipulating dynein and accessory protein activity using in vitro motility assays and living tissue culture cells. Importantly, we will also investigate the role of WebMar 7, 2024 · Dynein is a 1.4 MDa homodimeric complex of two heavy chains, which each binds smaller subunits, including the intermediate … Each molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. Cytoplasmic and axonemal dynein contain some of the same components, but they also contain some unique subunits. Cytoplasmic dynein, which has a molecular mass of about 1.5 megadaltons (MDa), is a dimer of dimers, containing approximately twelve polypeptide sub… somansh chordia

Cytoplasmic dynein-2 at a glance - The Company of Biologists

Functional interaction between dynein light chain and …

WebCentral to the function of this motor protein complex is dynein intermediate chain (IC), which binds the three dimeric dynein light chains at … WebCytoplasmic dynein is a member of the dynein superfamily of proteins. It is a massive multisubunit complex (1.2 MD) composed of two heavy chains (∼530 kD), three intermediate chains (74 kD), and four light intermediate chains (∼55 kD), and moves along microtubules toward their minus ends (13, 23) (Fig.5). small businesses near me listWebThe light intermediate chains associate in the dynein complex only as homoligomers. b ... LC4/Ca+2 binding: Related protein: ... Dynein is part of a complex including dynein … soma northwest

"WebMar 7, 2002 · Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Molecular Biology of the Cell 2011, 22 (15) , 2690 … " - Dynein light intermediate chain binding

Dynein light intermediate chain binding

Analysis of the Dynein-Dynactin Interaction In Vitro and In Vivo

Web13411 Ensembl ENSG00000105877 ENSMUSG00000018581 UniProt Q96DT5 n/a RefSeq (mRNA) NM_001277115 NM_010060 RefSeq (protein) NP_001264044 n/a Location (UCSC) Chr 7: 21.54 – 21.9 Mb Chr 12: 117.84 – 118.16 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Dynein axonemal heavy chain 11 (DNAH11), is a … WebIn both complexes, the heavy chain (HC) subunits hydrolyze ATP and interact with microtubules to generate force. The N-termini of the dynein HCs act as scaffolds for the accessory proteins, which include the dynein intermediate chain (IC), the dynein light-intermediate chains (LICs), and the dynein light chains (LCs) [1].

Did you know?

WebJun 5, 2024 · Cytoplasmic dynein plays crucial roles in the intracellular transport of organelles and other cargoes. Central to dynein function is the intrinsically disordered N-terminal domain of dynein intermediate chain (IC), which binds the three dimeric dynein light chains at multivalent sites, and dynactin p150 Glued and nuclear distribution … WebSpindly’s N-terminal coiled-coil uses distinct motifs to bind dynein light intermediate chain and the pointed-end complex of dynactin. Mutations in these motifs inhibit assembly of a dynein–dynactin–Spindly complex, and a null mutant of the dynactin pointed-end subunit p27 prevents kinetochore recruitment of dynein–dynactin without ...

WebMay 20, 2024 · Adaptor binding is governed by the homologous dynein light intermediate chain subunits LIC1 (DYNC1LI1) and LIC2 (DYNC1LI2), which exist in mutually … WebApr 16, 2024 · The dynein intermediate chains (DIC) have extended N termini that bind dimers of the dynein light chains Roadblock (Robl), LC8 and Tctex. The dynein light intermediate chain (DLIC) has an …

WebJun 1, 2002 · dynein light intermediate chain binding Source:GO_Central. 1 publication. Molecular Function: microtubule motor activity Source:UniProtKB. 1 publication. ... Consists of at least two heavy chains and a number of intermediate and light chains. Protein-protein interaction databases. BioGRID. 120722 7 interactors; IntAct. Q8TD57 6 … WebAug 1, 2011 · Cytoplasmic dynein consists of heavy chain (HC), intermediate chain (IC), light IC (LIC), and light chain (LC) subunits, ... The 8-kDa dynein light chain binds to …

WebMar 7, 2002 · Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Molecular Biology of the Cell 2011, 22 (15) , 2690-2701. DOI: 10.1091/mbc.e11-01-0075. ... The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proceedings of the National ...

WebThe dynein motor protein complex is required for retrograde transport but the functions of the intermediate-light chains that form the cargo-binding complex are not elucidated … small businesses near me hiringWebJan 1, 2024 · The dynein light chain 8 binding motif of rabies virus phosphoprotein promotes efficient viral transcription. Proc. Natl. Acad. Sci. U.S.A., 104 (2007), ... The … small businesses looking for helpWebRefSeq Summary (NM_001145154): Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major … small businesses natural organic minnesotaWebHere, we show that KASH5 promotes dynein motility in vitro, and cytosolic KASH5 inhibits dynein's interphase functions. KASH5 interacts with a dynein light intermediate chain (DYNC1LI1 or DYNC1LI2) via a conserved helix in the LIC C-terminal, and this region is also needed for dynein's recruitment to other cellular membranes. small businesses in winston salem ncWebMay 15, 2024 · The remarkable ability of dynein to interact with a diverse cargo spectrum stems from its tightly regulated recruitment of cargo-specific adaptor proteins, which … small businesses milwaukee wiWebCytoplasmic dynein and dynactin are megadalton-sized multisubunit molecules that function together as a cytoskeletal motor. In the present study, we explore the mechanism of dynein-dynactin binding in vitro and then extend our findings to an in vivo context. Solution binding assays were used to define binding domains in the dynein intermediate chain (IC) and … soman\u0027s tours and travelsWebWestin Hotels Near Ashburn The Westin Washington Dulles Airport. 4.7 miles from Ashburn Rooms from $197 2520 Wasser Terrace - Herndon. The Westin Reston Heights small businesses not helped by trump tax plan