Webb10 jan. 2024 · The removal of the mcr-1 gene from plasmid pHNSHP45 not only led to reduced resistance to colistin but also resulted in a significant change in the membrane permeability of E. coli. Unexpectedly, the removal of the mcr-1 gene increased cell viability under high osmotic stress conditions (e.g., 7.0% NaCl) and led to increased resistance to … Webb图4 大肠杆菌 SHP45 携带 mcr-1 基因质粒 pHNSHP45 的结构. 3. 多黏菌素耐药现状. 由于质粒介导的 mcr-1 基因可以在不同菌株间进行水平传播,致使动物源性多黏菌素类药物耐 …
Plasmid comparison of pRS1231-S-MCR-1.1 and pHNSHP45 …
Webb60 kb in-size, and were similar to pHNSHP45 (Fig. 1), the original sequenced mcr-1 plasmid published in 2015 [5]. The three IncI2 plasmids shared a common plasmid backbone, however, in the case of pPC11 the mcr-1 cas-sette [17] was located in an inverted orientation com-pared to the others (data not shown). Additionally, the WebbOne mcr-1-carrying Salmonella enterica serovar Indiana strain D90, was identified from 1320 Salmonella enterica isolates from poultry slaughterhouse in 2012 in China. The objective of this study was to verify the transferability of the mcr-1 gene and also completely characterize the sequence of the strain at the whole-genome level. Broth … canadian government purchases pipeline
Dissemination and Mechanism for the MCR-1 Colistin Resistance
Webb28 nov. 2016 · Abstract. Polymyxins are the last line of defense against lethal infections caused by multidrug resistant Gram-negative pathogens. Very recently, the use of polymyxins has been greatly challenged by the emergence of the plasmid-borne mobile colistin resistance gene ( mcr-1 ). However, the mechanistic aspects of the MCR-1 … Webb19 dec. 2016 · This recombination process enables the non-conjugative plasmid, pHYEC7-mcr1, to transfer its mcr-1-encoding mobile element to pHYEC7-IncHI2, forming a … Webb1 jan. 2016 · pHNSHP45 to the recipient strain. pHNSHP45 could be transferred via transformation, but not conjugation, into K pneumoniae 1202 (ST11) producing KPC-2, E coli E11 fisheries and oceans online licensing system