Webb10 apr. 2024 · For each cancer type, we first determined the appropriate soft threshold using the pickSoftThreshold function in the WGCNA v.1.69 R package. Webb5 sep. 2024 · Metastasis is a well-known poor prognostic factor and primary cause of mortality in patients with colorectal cancer (CRC). Recently, with the progress of high through-put sequencing, aberrantly expressed non-coding RNAs (ncRNAs) were found to participate in the initiation and development of cancer. However, the mechanisms of …
WGCNA: What is `soft thresholding`? - Bioconductor
Webb31 mars 2024 · A Computer Science portal for geeks. It contains well written, well thought and well explained computer science and programming articles, quizzes and practice/competitive programming/company interview Questions. WebbThe WGCNA package’s “pickSoftThreshold” x was used to find an acceptable - value for a scale-free network. The resulting adjacency matrix was transformed to a topological overlap matrix and used to determine dissimilarity values (1-TOM). 14 Topological overlap assesses the biological similarity between two genes based on their expression patterns. nervously silly
WGCNA/pickSoftThreshold.Rd at master · cran/WGCNA · GitHub
WebbFirst, an appropriate soft threshold was selected using the pickSoftThreshold function and was set at 6 (Figure 8A). In this study, β = 6 was chosen to construct the network, at which time the correlation coefficient between log(k) and log (p(k)) was close to 0.8 ( Figure 8B ). WebbFör 1 dag sedan · Then, the Hclust function in R was used to cluster the samples and eliminate abnormal individuals. According to the standard of the scale-free network, the "pickSoftThreshold" function in the WGCNA package was used to select a soft threshold of 9 to construct the weighted co-expression network and assess the connection between … Webb24 dec. 2024 · This parallel code is only available on platforms that have POSIX threads available (various Linux and Unix flavors and Mac OS). It is not available on Windows. … it takes two mary kate and ashley olsen